Senior Research Fellow
Jörg Schumacher obtained his Diplom in Biochemistry for the University of Cologne in 1994, for his work at the Agricultural Food Research Centre at Sussex University in biological nitrogen fixation of Azotobacter vinelandii (with Robert R. Eady). In 1999, he completed his PhD, where he studied the FixL-FixJ mediated regulation of nitrogen fixation genes in Sinorhizobium meliloti at the INRA/CNRS research centre in Toulouse, France (with Daniel Kahn). He joined Imperial College London in 2000, where he joined Martin Buck’s lab as a post-doc, studying the mechanism of sigma54 RNA-polymerase dependent transcription regulation involved in, among others, bacterial nitrogen regulation and plant microbe interactions. In 2011, he became group leader (research Fellow) and has established novel synthetic and systems biology approaches to enhance biological nitrogen fixation in plant associative diazotrophs.
- Synthetic and Systems Biology
Current N-related Projects:
Schumacher, J. † (2016) Native and synthetic gene regulation during adaptation to nitrogen limitation stress, In Environmental Control of Gene Expression and Adaptation in Bacteria. (Bruijn, F. J. D., Ed.) 1st ed., p 24, Blackwell/ Wiley. ISBN: 9781119004882
Gosztolai A, Schumacher J, Behrends V, Bundy JG, Heydenreich F, Bennett MH, et al. GlnK Facilitates the
Dynamic Regulation of Bacterial Nitrogen Assimilation. Biophysical journal. 2017;112(10):2219-30.
Paloma Bonato; Lysangela R. Alves; Juliana H. Osaki; Liu Un Rigo; Fabio O. Pedrosa; Emanuel M. Souza; Nan Zhang3, Jörg Schumacher, Martin Buck; Roseli Wassem; Leda S. Chubatsu. The NtrY/NtrX two-component system controls nitrate metabolism in Herbaspirillum seropedicae SmR1. In press, The FEBS Journal.
Wang, B. B., M.; Buck, M.; Schumacher, J. † (2014) Synthetic transcription factors allow regulon wide control and shifting the Nitrogen/Carbon balance in bacteria. NEW BIOTECHNOLOGY, Vol: 31, Pages: S22-S22, ISSN: 1871-6784.
Schumacher, J. †, Behrends, V., Pan, Z., Brown, D. R., Heydenreich, F., Lewis, M. R., Bennett, M. H., Razzaghi, B., Komorowski, M., Barahona, M., Stumpf, M. P., Wigneshweraraj, S., Bundy, J. G., and Buck, M. (2013) Nitrogen and carbon status are integrated at the transcriptional level by the nitrogen regulator NtrC in vivo, mBio 4, e00881-00813
Jovanovic, M., James, E. H., Burrows, P. C., Rego, F. G., Buck, M., and Schumacher, J. † (2011) Regulation of the co-evolved HrpR and HrpS AAA+ proteins required for Pseudomonas syringae pathogenicity, Nat Commun 2, 177.
Rappas, M., Schumacher, J., Beuron, F., Niwa, H., Bordes, P., Wigneshweraraj, S., Keetch, C. A., Robinson, C. V., Buck, M., and Zhang, X. (2005) Structural insights into the activity of enhancer-binding proteins, Science 307, 1972-1975.
Bordes, P., Wigneshweraraj, S. R., Schumacher, J., Zhang, X., Chaney, M., and Buck, M. (2003) The ATP hydrolyzing transcription activator phage shock protein F of Escherichia coli: identifying a surface that binds sigma 54, Proc Natl Acad Sci U S A 100, 2278-2283.
Da Re, S., Schumacher, J.*, Rousseau, P., Fourment, J., Ebel, C., and Kahn, D. (1999) Phosphorylation-induced dimerization of the FixJ receiver domain, Mol Microbiol 34, 504-511.
Birck, C., Mourey, L., Gouet, P., Fabry, B., Schumacher, J., Rousseau, P., Kahn, D., and Samama, J. P. (1999) Conformational changes induced by phosphorylation of the FixJ receiver domain, Structure 7, 1505-1515.
Schumacher J. (1997) Molecular mechanism of the response regulator FixJ. Molecular Microbiology, Vol 3, 334 pages. Springer Verlag ISBN 3-540-63873-3.